Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2169691 | Current Opinion in Cell Biology | 2016 | 10 Pages |
Abstract
As the first de novo actin nucleator discovered, the Arp2/3 complex has been a central player in models of protrusive force production via the dynamic actin network. Here, we review recent studies on the functional role of the Arp2/3 complex in the migration of diverse cell types in different migratory environments. These findings have revealed an unexpected level of plasticity, both in how cells rely on the Arp2/3 complex for migration and other physiological functions and in the intricate modulation of the Arp2/3 complex by other actin regulators and upstream signaling cascades.
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Authors
Kristen F Swaney, Rong Li,