| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2169737 | Current Opinion in Cell Biology | 2013 | 5 Pages |
Abstract
Piwi-interacting RNAs (piRNAs) were reported in 2006 as a novel class of small non-coding RNAs associated with Piwi proteins of the Argonaute/Piwi family. Recent studies have revealed not only the biogenesis of piRNAs and their roles in transposon silencing, but also the function of the Piwi-piRNA pathway in epigenetic and post-transcriptional regulation of gene expression. In addition, the function of this pathway in somatic cells has also been more systematically characterized. The new findings reveal the Piwi-piRNA pathway as a more general mechanism of gene regulation.
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Authors
Jamy C Peng, Haifan Lin,