| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2169817 | Current Opinion in Cell Biology | 2011 | 12 Pages |
Abstract
The target of rapamycin (TOR) is a highly conserved serine/threonine kinase and a central controller of cell growth, metabolism and aging. Mammalian TOR (mTOR) is activated in response to nutrients, growth factors and cellular energy. Dysregulated mTOR signaling has been implicated in major disease. Here we review recent findings on the role of mTOR in cancer, metabolic disorders, neurological diseases, and inflammation.
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Authors
Eva Dazert, Michael N Hall,