| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2169895 | Current Opinion in Cell Biology | 2011 | 6 Pages |
Autophagy is primarily a non-selective intracellular bulk degradation process. However, it was recently shown that ubiquitin-positive substrates, such as protein aggregates, mitochondria, peroxisomes, and invading bacteria, are selectively targeted to lysosomes via autophagy. Thus, ubiquitination seems to function as a general tag for selective autophagy in mammalian cells. This review discusses the present model of how autophagy sequesters invading bacteria through ubiquitination.
► Invading bacteria colocalize with poly-ubiquitinated proteins. ► Ubiquitination seems to function as a general tag for selective autophagy in mammalian cells. ► This review discusses the present model of how autophagy sequesters invading bacteria through ubiquitination.
