The plasticity of cytoskeletal dynamics underlying neoplastic cell migration

Due to the use of intra-vital imaging techniques and assays for cell migration into 3D matrices there has recently been much interest in different modes of tumour cell migration. Individually moving tumour cells can move either in an elongated-protrusive manner or in rounded, so-called ‘amoeboid’ modes. This review summarises ongoing efforts to delineate the cell signalling pathways that underlie these different forms of movement.