Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2169976 | Current Opinion in Cell Biology | 2010 | 8 Pages |
Abstract
Sex determination is regulated very differently in the soma vs. the germline, yet both processes are critical for the creation of the male and female gametes. In general, the soma plays an essential role in regulating sexual identity of the germline. However, in some species, such as Drosophila and mouse, the sex chromosome constitution of the germ cells makes an autonomous contribution to germline sexual development. Here we review how the soma and germline cooperate to determine germline sexual identity for some important model systems, the fly, the worm and the mouse, and discuss some of the implications of ‘dual control’ (soma plus germline) as compared to species where germline sex is dictated only by the surrounding soma.
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Authors
Sheryl M Murray, Shu Yuan Yang, Mark Van Doren,