Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2170151 | Current Opinion in Cell Biology | 2007 | 8 Pages |
Abstract
Coordinating terminal differentiation with permanent exit from the cell cycle is crucial for proper organogenesis, yet how the cell cycle is blocked in differentiated tissues remains unclear. Important roles for retinoblastoma family proteins and Cyclin-dependent kinase inhibitors have been delineated, but in many cases it remains unclear what triggers cell cycle exit. This review focuses on describing recent advances in deciphering how terminal differentiation and exit from the cell cycle are coordinated.
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Authors
Laura A Buttitta, Bruce A Edgar,