Article ID Journal Published Year Pages File Type
2170329 Current Opinion in Cell Biology 2006 9 Pages PDF
Abstract

At least eight of the twelve known members of the β1 integrin family are expressed on hematopoietic cells. Among these, the VCAM-1 receptor α4β1 has received most attention as a main factor mediating firm adhesion to the endothelium during blood cell extravasation. Therapeutic trials are ongoing into the use of antibodies and small molecule inhibitors to target this interaction and hence obtain anti-inflammatory effects. However, extravasation is only one possible process that is mediated by β1 integrins and there is evidence that they also mediate leukocyte retention and positioning in the tissue, lymphocyte activation and possibly migration within the interstitium. Genetic mouse models where integrins are selectively deleted on blood cells have been used to investigate these functions and further studies will be invaluable to critically evaluate therapeutic trials.

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Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology
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