Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2170465 | Cytokine & Growth Factor Reviews | 2014 | 5 Pages |
Abstract
B cell-activating factor belonging to the TNF family (BAFF) exerts its pathogenic role in supporting the survival and proliferation of B cells, regulating class switch recombination as well as the selection of autoreactive B cells. Overexpression of BAFF induces a dramatic expansion of activated B cells, particularly marginal zone B cells, as well as hypergammaglobulinemia, autoantibody production and immune complex deposition. However, in addition to its effect on B cells, recent work has also demonstrated that BAFF can promote T cell activation, proliferation and differentiation. In this review, we have discussed the recent progress on the function and role of BAFF on T cells and T cell-mediated diseases.
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Authors
Maogen Chen, Xiaohong Lin, Ya Liu, Qiang Li, Yiling Deng, Zhongmin Liu, David Brand, Zhiyong Guo, Xiaoshun He, Bernhard Ryffel, Song Guo Zheng,