Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2170670 | Cytokine & Growth Factor Reviews | 2010 | 10 Pages |
Abstract
Although initially identified and best characterized for their role in innate antiviral defence, type I interferons (IFN-I) are also known to have an important impact on the adaptive immune response. In part, this is linked to another long-recognised property of IFN-I, namely their ability to modify cellular proliferation and survival. Here, we review the influence of IFN-I on immune cell homeostasis, focusing on their effects on T cells and antigen-presenting cells.
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Authors
Fabrizio Mattei, Giovanna Schiavoni, David F. Tough,