Article ID Journal Published Year Pages File Type
2170795 Cytokine & Growth Factor Reviews 2009 5 Pages PDF
Abstract

A critical component of the innate immune response is the presence of germ line-encoded receptors capable of recognizing a wide variety of pathogen-associated molecules. One group of these receptors, the cytoplasmic RIG-I-like helicases (RLH), is involved in the induction of Type I interferon in response to viral infection. Here we discuss results of recent investigations into the initiation and transmission of signals through the RIG-I pathway.

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Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology
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