Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2170795 | Cytokine & Growth Factor Reviews | 2009 | 5 Pages |
Abstract
A critical component of the innate immune response is the presence of germ line-encoded receptors capable of recognizing a wide variety of pathogen-associated molecules. One group of these receptors, the cytoplasmic RIG-I-like helicases (RLH), is involved in the induction of Type I interferon in response to viral infection. Here we discuss results of recent investigations into the initiation and transmission of signals through the RIG-I pathway.
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Authors
J. Bradford Bowzard, Priya Ranjan, Suryaprakash Sambhara, Takashi Fujita,