Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2170841 | Cytokine & Growth Factor Reviews | 2007 | 11 Pages |
Abstract
The whole life of a B-cell from a stem cell to a mature plasma cell is governed, among other factors, by cytokines and growth factors in their microenvironment. Remarkable progress in the understanding of the mechanisms of cytokines action on the B-cell compartment was achieved by analysis of gene-targeted mice. The generation of mice deficient for individual cytokines or their receptors has shed light on the in vivo function of cytokines in B-cell responses. This review focuses on the role of cytokines in the development, maturation and differentiation of different B-cell subsets into antibody-secreting cells or memory B-cells.
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Authors
Eva V. Acosta-Rodríguez, Maria C. Merino, Carolina L. Montes, C. Cristina Motrán, Adriana Gruppi,