Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2170850 | Cytokine & Growth Factor Reviews | 2007 | 12 Pages |
Abstract
The possibility of inducing a strong immune response to impair tumor growth by ectopically expressing cytokines, followed by the generation of an antitumor memory raised great hopes and enthusiasm as a therapeutic approach. However, the efficacy of this strategy on established tumor models appeared low and the initial results in the clinics were disappointing. Recently, new evidence indicates that cytokine gene combination or the combined use of cytokine genes with additional gene therapy approaches induces a synergistic effect supporting the use of cytokine gene therapy to improve the clinical outcome for cancer patients.
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Authors
Osvaldo L. Podhajcer, María Verónica Lopez, Guillermo Mazzolini,