Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2170970 | Cytokine & Growth Factor Reviews | 2006 | 9 Pages |
Abstract
Cytokines are produced in a variety of tissues and regulate the expression of a number of inflammatory molecules, leading to destabilization and finally rupture of vulnerable atheromatic plaques. They also participate in the pathophysiology of acute coronary syndromes (ACS) by direct effects on myocardial contractility and apoptosis. At a clinical level, circulating cytokines have a prognostic role since they are useful markers predicting future coronary events in patients with advanced atherosclerosis and in patients after ACS.
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Authors
Dimitris Tousoulis, Charalambos Antoniades, Nikolaos Koumallos, Christodoulos Stefanadis,