| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2170973 | Cytokine & Growth Factor Reviews | 2006 | 22 Pages |
Abstract
The cytokine interleukin-15 (IL-15) has a key role in promoting survival, proliferation and activation of natural killer (NK) and CD8+ T cells. Despite its functional similarities to IL-2, IL-15 affects a wider range of target cell populations and utilizes different mechanisms of signaling. Here, we review recent advances in the IL-15-mediated signaling, and in the functional properties on cells besides T lymphocytes and NK cells. These are discussed in the context of their potential clinical and therapeutic relevance.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Vadim Budagian, Elena Bulanova, Ralf Paus, Silvia Bulfone-Paus,