Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2170988 | Cytokine & Growth Factor Reviews | 2006 | 10 Pages |
Abstract
TGF-β is a pleiotropic cytokine with powerful immunosuppressive functions. Mice deficient for TGF-β1 show a dramatic phenotype with severe multiorgan inflammation and die shortly after birth. Recent investigations have highlighted the role of TGF-β in suppression of T cell mediated autoimmune inflammation and anti-tumor immunity. In addition to its direct anti-inflammatory effects on T cells, TGF-β has been implicated as central regulator of regulatory T cells. TGF-β not only mediates the suppression of effector T cells by Tregs, recent evidence also reveals a role for TGF-β along with TCR stimulation in the peripheral induction of regulatory T cells from naïve CD4+CD25− cells.
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Authors
Christoph Becker, Massimo C. Fantini, Markus F. Neurath,