Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2171261 | Cytotherapy | 2013 | 7 Pages |
Abstract
Mesenchymal stromal cells (MSCs) are multipotent progenitor cells capable of differentiating into adipocytes, osteoblasts and chondroblasts as well as secreting a vast array of soluble mediators. This potentially makes MSCs important mediators of a variety of therapeutic applications. They are actively under evaluation for immunomodulatory purposes such as graft-versus-host disease and Crohn’s disease as well as regenerative applications such as stroke and congestive heart failure. We report our method of generating clinical-grade MSCs together with suggestions gathered from manufacturing experience in our Good Manufacturing Practices facility.
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Authors
Patrick J. Hanley, Zhuyong Mei, Maria da Graca Cabreira-Hansen, Mariola Klis, Wei Li, Yali Zhao, April G. Durett, Xingwu Zheng, Yongping Wang, Adrian P. Gee, Edwin M. Horwitz,