| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2172210 | Cytotherapy | 2010 | 8 Pages |
Abstract
Because of the necessary immunodepletion prior to cord blood transplantation as well as the immaturity of cord blood immune cells, recipients experience a high incidence of viral infection in addition to complications observed after hematopoietic stem cell transplantation, such as relapse and graft-versus-host disease. We describe current immunotherapeutic approaches to treating these complications, including the generation of antigen-specific T cells from cord blood, redirecting cord blood T cells using chimeric antigen receptors, and generating cord blood-derived natural killer cells and regulatory T cells.
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Authors
Patrick J. Hanley, Conrad Russell Cruz, Elizabeth J. Shpall, Catherine M. Bollard,