| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2173306 | Developmental Biology | 2012 | 9 Pages |
Abstract
Boundary Element Associated Factor-32 (BEAF-32) is an insulator protein predominantly found near gene promoters and thought to play a role in gene expression. We find that mutations in BEAF-32 are lethal, show loss of epithelial morphology in imaginal discs and cause neoplastic growth defects. To investigate the molecular mechanisms underlying this phenotype, we carried out a genome-wide analysis of BEAF-32 localization in wing imaginal disc cells. Mutation of BEAF-32 results in miss-regulation of 3850 genes by at lea
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Authors
B.V. Gurudatta, Edward Ramos, Victor G Corces,