| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2173423 | Developmental Biology | 2012 | 25 Pages |
Abstract
⺠The transcription factor Gfi1b defines the brush cell lineage and its progenitors. ⺠Enforced Notch signaling reduces but does not eliminate brush cell formation. ⺠Brush cell numbers increase dramatically in Atoh1-deficient epithelium. ⺠Brush cells are not a granulocytic (secretory) or columnar (absorptive) lineage. ⺠Hes1, Atoh1, and Gfi1b form a fate-determining Notch signaling driven ternary switch.
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Authors
Matthew Bjerknes, Cyrus Khandanpour, Tarik Möröy, Tomoyuki Fujiyama, Mikio Hoshino, Tiemo J. Klisch, Qian Ding, Lin Gan, Jiafang Wang, MartÃn G. MartÃn, Hazel Cheng,