| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2173933 | Developmental Biology | 2010 | 5 Pages |
Abstract
The left–right (LR) axis is essential for the proper function of internal organs. In mammals and fish, left-sided Nodal expression governs LR patterning. Here, we show that the Polycomb group protein Ezh1, which is highly conserved from fish to human, participates in LR patterning. Knockdown of olezh1, a medaka homologue of Ezh1, led to LR reversal of internal organs. It was shown that OLEZH1 acts in silencing the expression of Spaw (a medaka homolog of Nodal) via a previously unknown pathway. Furthermore, coimmunoprecipitation showed physical interaction of Ezh1 with FoxH1, a Nodal regulator. This represents a novel mechanism for LR patterning and implies that Ezh1 has developmental importance.
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Authors
Daisuke Arai, Hiroaki Katsura, Norihisa Shindo, Mayuko Matsumoto, Toru Higashinakagawa,