Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2173946 | Developmental Biology | 2010 | 10 Pages |
Abstract
During embryonic development, the vertebrate vasculature is undergoing vast growth and remodeling. Blood vessels can be formed by a wide spectrum of different morphogenetic mechanisms, such as budding, cord hollowing, cell hollowing, cell wrapping and intussusception. Here, we describe the vascular morphogenesis that occurs in the early zebrafish embryo. We discuss the diversity of morphogenetic mechanisms that contribute to vessel assembly, angiogenic sprouting and tube formation in different blood vessels and how some of these complex cell behaviors are regulated by molecular pathways.
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Authors
Elín Ellertsdóttir, Anna Lenard, Yannick Blum, Alice Krudewig, Lukas Herwig, Markus Affolter, Heinz-Georg Belting,