Article ID Journal Published Year Pages File Type
2175464 Developmental Biology 2007 13 Pages PDF
Abstract

The basis for Hydra's enormous regeneration capacity is the “stem cellness” of its epithelium which continuously undergoes self-renewing mitotic divisions and also has the option to follow differentiation pathways. Now, emerging molecular tools have shed light on the molecular processes controlling these pathways. In this review I discuss how the modular tissue architecture may allow continuous replacement of cells in Hydra. I also describe the discovery and regulation of factors controlling the transition from self-renewing epithelial stem cells to differentiated cells.

Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology
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