Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2177153 | Developmental Cell | 2010 | 14 Pages |
SummaryCell competition promotes the elimination of weaker cells from a growing population. Here we investigate how cells of Drosophila wing imaginal discs distinguish “winners” from “losers” during cell competition. Using genomic and functional assays, we have identified several factors implicated in the process, including Flower (Fwe), a cell membrane protein conserved in multicellular animals. Our results suggest that Fwe is a component of the cell competition response that is required and sufficient to label cells as “winners” or “losers.” In Drosophila, the fwe locus produces three isoforms, fweubi, fweLose-A, and fweLose-B. Basal levels of fweubi are constantly produced. During competition, the fweLose isoforms are upregulated in prospective loser cells. Cell-cell comparison of relative fweLose and fweubi levels ultimately determines which cell undergoes apoptosis. This “extracellular code” may constitute an ancient mechanism to terminate competitive conflicts among cells.
► Flower (Fwe) is a conserved cell membrane protein ► During cell competition in fly imaginal discs, Fwe determines “winners” and “losers” ► A ubiquitous Fwe isoform promotes cell survival ► Fwe isoforms produced only by “loser” cells induce cell death