Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2177891 | Developmental Cell | 2006 | 10 Pages |
Abstract
Essentially all organisms from bacteria to humans are mechanosensitive. Physical forces regulate a large array of physiological processes, and dysregulation of mechanical responses contributes to major human diseases. A survey of both specialized and widely expressed mechanosensitive systems suggests that physical forces provide a general means of altering protein conformation to generate signals. Specialized systems differ mainly in having acquired efficient mechanisms for transferring forces to the mechanotransducers.
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Authors
A. Wayne Orr, Brian P. Helmke, Brett R. Blackman, Martin A. Schwartz,