Article ID Journal Published Year Pages File Type
2177891 Developmental Cell 2006 10 Pages PDF
Abstract

Essentially all organisms from bacteria to humans are mechanosensitive. Physical forces regulate a large array of physiological processes, and dysregulation of mechanical responses contributes to major human diseases. A survey of both specialized and widely expressed mechanosensitive systems suggests that physical forces provide a general means of altering protein conformation to generate signals. Specialized systems differ mainly in having acquired efficient mechanisms for transferring forces to the mechanotransducers.

Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology
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