Characterization of PEDOT:PSS-reduced graphene oxide@Pd composite electrode and its application in voltammetric determination of vitamin K3

•PEDOT:PSS-reduced graphene oxide @ Pd composite for the fabrication of sensor•The as-obtained sensor displayed the synergistically enhanced electrocatalytic ability and superior sensing performance.•The proposed method was employed for voltammetric determination of vitamin K3 in animal blood and feed samples.

Vitamin K3 (VK3), a synthetic blood coagulation vitamin with fat-solubility, easily results in side-effect in animal body due to its toxicity and improper addition of animal feedstuffs. In this study, a novel sensor based on glassy carbon electrode (GCE) modified with a conducting polymer-both nano-noble metals and two-dimensional nano-carbon composite consisting of poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS), carboxymethyl cellulose (CMC) and reduced graphene oxide@palladium (rGO@Pd) was successfully used for the voltammetric detection of VK3 in animal blood and feedstuff samples. Under the optimized conditions, PEDOT:PSS-CMC-rGO@Pd/GCE/GCE displayed the excellent synergistically electrocatalytic ability for the electrochemical oxidation-reduction of VK3, which exhibited a good voltammetric response for VK3 in the concentration range from 4 × 10− 7 to 9 × 10− 5 M, with a limit of detection of 1.4 × 10− 8 M. Furthermore, a facile preparation, high sensitivity, good selectivity, superior sensing stability, and satisfactory practicability of PEDOT:PSS-CMC-rGO@Pd/GCE/GCE for sensing VK3 suggested that the potential applicability of PEDOT:PSS-CMC-rGO@Pd provided a promising electrochemical sensing platform for the determination of VK3 in pharmaceutical and feed inspection.

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