Electrochemical oxidation behavior of itraconazole at different electrodes and its anodic stripping determination in pharmaceuticals and biological fluids

•Optimization condition of experiment such as pH, accumulation time and accumulation potential•Behavior of ITZ at different electrodes•Suggested mechanism of ITZ•Differential pulse voltammetry used to perform a calibration curve•Square wave voltammetry used to perform a calibration curve•Application to pharmaceutical dosage forms and biological fluids•Validation of the results

The oxidation of itraconazole at three different electrodes; ultra-trace graphite (UTGE), pencil graphite (PGE) and carbon paste (CPE) electrodes were studied voltammetrically. After the optimization of solution pH, accumulation potential and accumulation time, anodic stripping differential pulse and anodic stripping square wave voltammetric peaks were obtained. The oxidation mechanism was proposed. Based on these findings, a simple and not time-consuming procedure was successfully applied for the determination of itraconazole in pharmaceutics and biological fluids.

Graphical abstractThe electrochemical behavior of itraconazole at an ultra-trace graphite electrode.Figure optionsDownload full-size imageDownload as PowerPoint slide