Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2181116 | Fungal Genetics and Biology | 2009 | 11 Pages |
Abstract
Several published functions associated with the CHK1 histidine kinase of Candida albicans resemble those of the MAPK Cek1p and its cognate receptor Sho1p (SSU81). To explore this further, we have compared mutants lacking the proteins mentioned above and have constructed a double sho1/chk1Δ null mutant to determine relationships among these proteins. We observed that the sensitivity to Congo red (CR), calcofluor white (CW), as well as clumping of cells, was slightly increased in the double mutant compared to the single chk1Δ or sho1Δ mutants. However, Cek1p phosphorylation via Sho1p, which occurs
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Authors
Dongmei Li, David Williams, Douglas Lowman, Mario A. Monteiro, Xuan Tan, Michael Kruppa, William Fonzi, Elvira Roman, Jesus Pla, Richard Calderone,