Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2181677 | Fungal Genetics and Biology | 2007 | 13 Pages |
Abstract
We isolated and characterized a novel spontaneous longevity mutant of Podospora anserina strain Wa32 carrying one of the pAL2-1 homologous mitochondrial plasmids. This mutant is at least ten fold longer-lived than the wild type, and is hence a formal suppressor of both the regular and the 'plasmid-based' senescence process. We show that the longevity trait is maternally inherited and coincides with the presence of a copy of the plasmid integrated in the 5â² UTR of the mitochondrial Complex I genes nd2 and nd3. This mutation is associated with complex alterations in the respiratory chain, including a dispensable induction of the alternative oxidase. It is also associated with a stabilization of the mitochondrial chromosome and a reduction of the overall cellular level of reactive oxygen species.
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Authors
M.F.P.M. Maas, C.H. Sellem, R.F. Hoekstra, A.J.M. Debets, A. Sainsard-Chanet,