| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2181944 | Gene Expression Patterns | 2012 | 10 Pages |
Visinin like 1 (Vsnl1) encodes a calcium binding protein which is well conserved between species. It was originally found in the brain and its biological functions in central nervous system have been addressed in several studies. Low expression levels have also been found in some peripheral organs, but very little information is available regarding its physiological roles in non-neuronal tissues. Except for the kidney, the expression pattern of Vsnl1 mRNA and protein has not yet been addressed during embryogenesis. By in situ hybridization and immunolabeling we have extensively analyzed the expression pattern of Vsnl1 during murine development. Vsnl1 specifies the cardiac primordia and its expression becomes restricted to the atrial myocardium after heart looping. However, in the adult heart, Vsnl1 is expressed by all four cardiac chambers. It also serves as a specific marker for the cardiomyocyte-derived structures in the systemic and pulmonary circulation. Vsnl1 is dynamically expressed also by many other organs during development e.g. taste buds, cochlea, thyroid, tooth, salivary and adrenal gland. The stage specific expression pattern of Vsnl1 makes it a potentially useful marker particularly in studies of cardiac and vascular morphogenesis.
Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (135 K)Download as PowerPoint slideHighlights► We presently analyzed the expression pattern of Vsnl1 during mouse embryogenesis. ► Vsnl1 specifies the cardiac anlagen and cardiac venous pole early in development. ► It is a new cardiomyocyte marker confined to all components of atrial myocardium. ► It is a potentially useful marker in studies of cardiac and vascular morphogenesis.
