Article ID Journal Published Year Pages File Type
2182410 Gene Expression Patterns 2007 10 Pages PDF
Abstract

The atypical C-type protein kinases (aPKCs) comprise the third subclass of the PKC family functionally defined by insensitivity to phorbol esters, diacylgylcerol and calcium. aPKCs have been implicated in numerous biological processes including cell proliferation and survival, cell polarity, migration and inflammation. However, only insufficient data exist with regard to aPKC isoform specificity, since both mammalian aPKCs, PKC ι/λ and PKC ζ, exhibit a high structural homology and very similar biochemical properties. In this study, we therefore used isoform-specific riboprobes and antibodies to define the characteristic expression profile of each aPKC isoform during mouse embryogenesis. Both, PKC ι/λ and ζ show highly specific temporal and spatial patterns of expression which may help in distinguishing physiological functions of these isoforms.

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Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology
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