| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2182616 | Genes & Diseases | 2016 | 9 Pages |
Abstract
The attenuated anaerobic bacterium Clostridium novyi-NT (C. novyi-NT) is known for its ability to precisely germinate in and eradicate treatment-resistant hypoxic tumors in various experimental animal models and spontaneously occurring canine sarcomas. In this article, we review the therapeutic and toxicologic aspects of C. novyi-NT therapy, key challenges and limitations, and promising strategies to optimize its performance via recombinant DNA technology and immunotherapeutic approaches, to establish C. novyi-NT as an essential tool in cancer therapy.
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Authors
Verena Staedtke, Nicholas J. Roberts, Ren-Yuan Bai, Shibin Zhou,