Article ID Journal Published Year Pages File Type
2183197 Immunobiology 2014 8 Pages PDF
Abstract
Our data indicate that during monopoiesis the proximal IL-6 promoter is reorganized into an accessible conformation allowing transcription of IL-6 after LPS stimulation. DNA methylation appears to be the essential epigenetic mechanism in IL-6 gene expression of mature monocytes and their progenitors by controlling the chromatin structure.
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Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology
Preview
Regulation of the Interleukin-6 gene expression during monocytic differentiation of HL-60 cells by chromatin remodeling and methylation
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