Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2183519 | Immunobiology | 2012 | 9 Pages |
Abstract
Hyaluronan (HA), a component of the extracellular matrix surrounding tumors, modulates tumor progression and the immune response. Dendritic cells (DC) may tolerize or stimulate immunity against cancer. In this report, we study the association between tumor progression, HA levels and DC activation in a lymphoma model. Mice injected with the cells with highest invasive capacity (LBR-) presented increased HA in serum and lymph nodes, and decreased DC activation in infiltrated lymph nodes and liver. These findings could be related to lack of an effective antitumor immune response and suggest that serum HA levels could have a prognostic value in hematological malignancies.
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Authors
Rosalia I. Cordo Russo, Glenda Ernst, Silvina Lompardía, Guillermo Blanco, Élida Álvarez, Mariana G. Garcia, Silvia Hajos,