Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2184020 | Immunobiology | 2007 | 10 Pages |
Abstract
Peritoneal macrophages suppressed T lymphocyte activation by amino acid catabolism. CTLA-4-Ig complemented this form of suppression by blocking the costimulation of T cells. Inhibition of the amino acid catabolizing enzymes or blockade of the IFNγ signaling essential for macrophage-mediated suppression did not impact CTLA-4-Ig efficacy. Except for phytohemagglutinin, T cell responses to superantigen, mitogen, and anti-CD3 were further reduced when CTLA-4-Ig was combined with peritoneal macrophages. The combination of these complimentary forms of immune regulation potently suppresses adaptive immunity.
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Authors
Kenny Yeh, Daniel Silberman, Diana Gonzalez, James Riggs,