| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2185428 | Journal of Molecular Biology | 2011 | 8 Pages |
Abstract
X-chromosome inactivation (XCI) ensures dosage compensation in mammals. Random XCI is a process where a single X chromosome is silenced in each cell of the epiblast of mouse female embryos. Operating at the level of an entire chromosome, XCI is a major paradigm for epigenetic processes. Here we review the most recent discoveries concerning the role of long noncoding RNAs, pluripotency factors, and chromosome structure in random XCI.
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Authors
Philippe Clerc, Philip Avner,