Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2189056 | Journal of Molecular Biology | 2006 | 11 Pages |
Abstract
FKBP42 is a membrane-anchored immunophilin playing a critical role in morphogenesis and development of higher plants. We present the X-ray structure of the cytoplasmic portion of FKBP42 comprising both the FKBP-like domain and the TPR domain at 2.85 Å resolution. The data shed light on the probable binding modes of key interaction partners, including HSP90 and two classes of ABC transporters. The resulting models provide a structural background for further investigation of the unique biological properties of this protein.
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Authors
Joachim Granzin, Andreas Eckhoff, Oliver H. Weiergräber,