Voltammetric determination of verapamil and propranolol using a glassy carbon electrode modified with functionalized multiwalled carbon nanotubes within a poly (allylamine hydrochloride) film

•A GCE modified with MWCNT within a PAH was used to develop the novel sensor.•VPM is determined by square-wave adsorptive anodic stripping voltammetry.•PROP is determined by differential-pulse adsorptive anodic stripping voltammetry.•The MWCNTs presented an electrocatalytic activity and increased analytical signal.•The obtained results are in agreement with those obtained using a comparative methods.

In this report, we describe the individual determination of verapamil (VPM) and propranolol (PROP) in pharmaceutical formulations using square-wave adsorptive anodic stripping voltammetry (SWAdASV), differential-pulse adsorptive anodic stripping voltammetry (DPAdASV), and a glassy carbon electrode modified with functionalized multiwalled carbon nanotubes within a poly (allylamine hydrochloride) film. The anodic peak potential for VPM and PROP at this modified electrode was 1.09 V and 0.930 V (versus Ag/AgCl (3.0 mol L−1 KCl)), respectively, in a 0.25 mol L−1 H2SO4 solution. Under optimized SWAdASV and DPAdASV conditions, the obtained analytical curves were linear for VPM concentrations ranging from 5.0 × 10−9 to 1.1 × 10−7 mol L−1, and PROP concentrations ranging from 7.4 × 10−8 to 1.0 × 10−6 mol L−1, with detection limits of 3.6 × 10−9 mol L−1 and 2.6 × 10−8 mol L−1, respectively. Both of the proposed methods were successfully applied for the individual determination of VPM and PROP in several pharmaceutical formulations. The results were in a close agreement with a 95% confidence level for those obtained using official spectrophotometric methods.