| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2190801 | Journal of Molecular and Cellular Cardiology | 2011 | 7 Pages |
Abstract
⺠Our goal was to study the role of titin-based viscosity in diastolic function. ⺠The titin PEVK element interacts in vitro with actin to create viscosity; we used a mouse deficient in PEVK. ⺠PEVK KO reduces viscosity > 50% in skinned tissue in vitro and > 30% in hearts in vivo. ⺠The PEVK-actin interaction is an important physiologic source of viscosity.
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Authors
Charles S. Chung, Methajit Methawasin, O. Lynne Nelson, Michael H. Radke, Carlos G. Hidalgo, Michael Gotthardt, Henk L. Granzier,