Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2192081 | Journal of Molecular and Cellular Cardiology | 2007 | 10 Pages |
Abstract
The Kruppel-like Factor (KLF) family of zinc-finger transcription factors are critical regulators of cell differentiation, phenotypic modulation and physiologic function. An emerging body of evidence implicates an important role for these factors in cardiovascular biology, however, the role of KLFs in muscle biology is only beginning to be understood. This article reviews the published data describing the role of KLFs in the heart, smooth muscle, and skeletal muscle and highlights the importance of these factors in cardiovascular development, physiology and disease pathobiology.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Saptarsi M. Haldar, Osama A. Ibrahim, Mukesh K. Jain,