Simultaneous electrochemical detection of the catecholamines and ascorbic acid at PEDOT/S-β-CD modified gold electrodes

Poly (3,4-ethylene dioxythiophene)/sulphated β-cyclodextrin (PEDOT/S-β-CD) films, deposited onto gold working electrodes, were investigated for ascorbic acid (AA) and catecholamine detection using cyclic voltammetry, hydrodynamic voltammetry and amperometry. The thin PEDOT/S-β-CD films were fabricated via three electropolymerisation cyclic voltammetry cycles, on gold working macroelectrodes. A limit of detection (LoD) of 1.3 × 10−7 M was determined at PEDOT/S-β-CD modified gold electrodes, via cyclic voltammetry, for dopamine (DA) in the presence of 1 × 10−3 M of AA in human urine samples.

► PEDOT modified electrodes fabricated from aqueous solution using sole dopant S-β-CD. ► Modified electrodes detect ascorbic acid and catecholamines simultaneously. ► Detection of 1 μM catecholamine in the presence of 1 mM ascorbic acid in human urine samples was achieved.