Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2195158 | Mechanisms of Development | 2010 | 7 Pages |
Abstract
The innate immune response is a defense mechanism against infectious agents in both vertebrates and invertebrates, and is in part mediated by the Toll pathway. Toll receptor activation upon exposure to bacteria causes stimulation of Pelle/IRAK kinase, eventually resulting in translocation of the transcription factor NF-κB to the nucleus. Here we show that Pellino, a highly conserved protein interacting with activated Pelle/IRAK, acts as a positive regulator of innate immunity in Drosophila.
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Authors
Amirhossein Haghayeghi, Amila Sarac, Stefan Czerniecki, Jörg Grosshans, Frieder Schöck,