| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2196281 | Molecular and Cellular Endocrinology | 2012 | 6 Pages |
Abstract
⺠We test GH and PRL secretion and gene expression in human GH/PRL-secreting tumors. ⺠SST2 and SST5 agonists and SRIF/DA decrease GH secretion, but not GH mRNA levels. ⺠SRIF/DA and D2 agonist BIM-53097 inhibit both PRL secretion and PRL gene expression. ⺠SST5 agonist inhibits PRL secretion, but does not suppress PRL gene expression. ⺠D2 affinity has a crucial role in the action of SRIF/DA on PRL gene expression.
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Authors
Anna Gruszka, Michael D. Culler, Shlomo Melmed,