Article ID Journal Published Year Pages File Type
2196384 Molecular and Cellular Endocrinology 2012 12 Pages PDF
Abstract

In tissues which express the mineralocorticoid receptor (MR), aldosterone modulates the expression of membrane targets such as the subunits of the epithelial Na+ channel, in combination with important signalling intermediates such as serum and glucocorticoid-regulated kinase-1. In addition, the rapid ‘non-genomic’ activation of protein kinases and secondary messenger signalling cascades has also been detected in aldosterone-sensitive tissues of the nephron, distal colon and cardiovascular system. These rapid actions are variously described as being coupled to MR or to an as yet unidentified, membrane-associated aldosterone receptor. The rapidly activated signalling cascades add a level of fine-tuning to the activity of aldosterone-responsive membrane transporters and also modulate the aldosterone-induced changes in gene expression through receptor and transcription factor phosphorylation.

► Aldosterone-induced signalling cascades (MAPK, PKC). ► Crosstalk between rapid and genomic effects of aldosterone. ► Ion transport targets of rapid responses to aldosterone (ENaC, NHE).

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