| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2197462 | Molecular and Cellular Endocrinology | 2009 | 6 Pages |
Abstract
Calorie restriction (CR) is a non-genetic manipulation that reliably results in extended lifespan of several species ranging from yeast to dogs. The lifespan extension effect of CR has been strongly associated with an increased level and activation of the silent information regulator 2 (Sir2) histone deacetylase and its mammalian ortholog Sirt1. This association led to the search for potential Sirt1-activating, life-extending molecules. This review briefly outlines the experimental findings on resveratrol and other dietary activators of Sirt1.
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Authors
Joanne S. Allard, Evelyn Perez, Sige Zou, Rafael de Cabo,