Gold nanoparticles/ethylenediamine/carbon nanotube modified glassy carbon electrode as the voltammetric sensor for selective determination of rutin in the presence of ascorbic acid

In this paper, the electrochemical behavior of rutin on a gold nanoparticles/ethylenediamine/multi-wall carbon nanotubes modified glassy carbon electrode (AuNPs/en/MWNTs/GCE) was investigated and the electrochemical parameters of rutin were calculated. Rutin effectively accumulated on the AuNPs/en/MWNTs/GCE and caused a pair of redox peaks at around 487 mV and 432 mV (vs. SCE) in 0.1 M phosphate buffer solution (pH 3.5). Under optimized conditions, the anodic peak current was linear to the rutin concentration in the range of 4.8 × 10−8 M−9.6 × 10−7 M. The regression equation was: ipa = 2.3728Crutin−0.1782 (ipa: 10−5 A, Crutin: μM, r = 0.9973). The detection limit of 3.2 × 10−8 M was obtained. The proposed method was successfully used to the determination of rutin content in tablet samples with satisfactory results.