Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2197647 | Molecular and Cellular Endocrinology | 2008 | 5 Pages |
Abstract
The somatostatin receptor subtypes 1–5 (sst1–sst5) exhibit different intracellular trafficking and endosomal sorting after agonist exposure. The internalization of the somatostatin receptor subtypes sst2, sst3 and sst5 occurs to a much higher extent after somatostatin exposure than of sst1 or sst4. After endocytosis, sst2 and sst5 recycle to the plasma membrane, whereas sst3 is predominantly down-regulated. This review will focus on the molecular mechanisms of the differential intracellular trafficking of sst2, sst3 and sst5, and discusses our current knowledge on somatostatin receptor interacting proteins.
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Authors
Stefan Jacobs, Stefan Schulz,