Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2197685 | Molecular and Cellular Endocrinology | 2008 | 7 Pages |
Abstract
Understanding how β-cells maintain themselves in the adult pancreas is important for prioritizing strategies aimed at ameliorating or ideally curing different forms of diabetes. There has been much debate over whether β-cell proliferation, as a means of self-renewal, predominates over the existence and differentiation of a pancreatic stem cell or progenitor cell population. This article describes the two opposing positions based largely on research in laboratory rodents and its extrapolation to humans.
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Authors
Neil A. Hanley, Karen Piper Hanley, Päivi J. Miettinen, Timo Otonkoski,