| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2197877 | Molecular and Cellular Endocrinology | 2007 | 10 Pages |
Abstract
Retinoic acid receptors (RARs) activate transcription by recruiting coactivator complexes such as histone acetyltransferases (HAT) and the mediator complex, to increase chromatin accessibility by general transcription factors and to promote transcription initiation. Indirect evidences have suggested a role for the ATP-dependent chromatin remodeling complex SWI/SNF in RAR-mediated transcription. Here we demonstrate that two highly related subunits of the core SWI/SNF complex, BAF60c1 and BAF60c2, interact physically with retinoid receptors and are coactivators for RARs. This coactivating property is dependent on SRC1 expression, showing that HATs and SWI/SNF cooperate in this retinoid-controlled transcriptional process.
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Authors
Sébastien Flajollet, Bruno Lefebvre, Céline Cudejko, Bart Staels, Philippe Lefebvre,