Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2197953 | Molecular and Cellular Endocrinology | 2007 | 5 Pages |
Abstract
If human papillomavirus (HPV) is necessary for the development of (pre)neoplastic lesions of the uterine cervix, it is not sufficient. Among the cofactors involved in the malignant transformation of cells infected by HPV, sex hormones may facilitate the cervical carcinogenesis by different mechanisms, including the induction of squamous metaplasia in the transformation zone of the cervix, interactions between steroid hormones and HPV gene expression and alterations of the local immune microenvironment.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Philippe Delvenne, Ludivine Herman, Natalia Kholod, Jean-Hubert Caberg, Michaƫl Herfs, Jacques Boniver, Nathalie Jacobs, Pascale Hubert,